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βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy

 

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Opened Access βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy
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Author: Herrero Ruiz, Joaquín
Mora Santos, María del Mar
Giraldez Macias, Servando
Sáez Torres, Carmen
Romero Portillo, Francisco
Japón Rodríguez, Miguel Ángel
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2014
Published in: Oncotarget, 5 (17), 7563-7574.
Document type: Article
Abstract: n mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the regulation of the G2/M transition, G1 progression and G1/S transition. CDK1 is highly regulated by its association to cyclins,...
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Cite: Herrero Ruiz, J., Mora Santos, M.d.M., Giraldez Macias, S., Sáez Torres, C., Romero Portillo, F. y Japón Rodríguez, M.Á. (2014). βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy. Oncotarget, 5 (17), 7563-7574.
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URI: http://hdl.handle.net/11441/61074

DOI: 10.18632/oncotarget.2274

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