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dc.creatorHerrero, Enriquees
dc.creatorWellinger, Ralf Erikes
dc.date.accessioned2017-06-01T10:20:20Z
dc.date.available2017-06-01T10:20:20Z
dc.date.issued2015
dc.identifier.citationHerrero, E. y Wellinger, R.E. (2015). Yeast as a model system to study metabolic impact of selenium compounds. Microbial Cell, 2 (5), 139-149.
dc.identifier.issn2311-2638es
dc.identifier.urihttp://hdl.handle.net/11441/60728
dc.description.abstractInorganic Se forms such as selenate or selenite (the two more abundant forms in nature) can be toxic in Saccharomyces cerevisiae cells, which constitute an adequate model to study such toxicity at the molecular level and the functions participating in protection against Se compounds. Those Se forms enter the yeast cell through other oxyanion transporters. Once inside the cell, inorganic Se forms may be converted into selenide through a reductive pathway that in physiological conditions involves reduced glutathione with its consequent oxidation into diglutathione and alteration of the cellular redox buffering capacity. Selenide can subsequently be converted by molecular oxygen into elemental Se, with production of superoxide anions and other reactive oxygen species. Overall, these events result in DNA damage and dose-dependent reversible or irreversible protein oxidation, although additional oxidation of other cellular macromolecules cannot be discarded. Stress-adaptation pathways are essential for efficient Se detoxification, while activation of DNA damage checkpoint and repair pathways protects against Se-mediated genotoxicity. We propose that yeast may be used to improve our knowledge on the impact of Se on metal homeostasis, the identification of Se-targets at the DNA and protein levels, and to gain more insights into the mechanism of Se-mediated apoptosis.es
dc.description.sponsorshipEspaña, Junta de Andalucía P11-CTS- 7962es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherShared Science Publisherses
dc.relation.ispartofMicrobial Cell, 2 (5), 139-149.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectseleniumes
dc.subjectyeastes
dc.subjectDNA damagees
dc.subjectoxidative stresses
dc.subjectmitochondrial functiones
dc.subjectsignal transductiones
dc.titleYeast as a model system to study metabolic impact of selenium compoundses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.projectIDP11-CTS- 7962es
dc.relation.publisherversionhttp://dx.doi.org/10.15698/mic2015.05.200es
dc.identifier.doi10.15698/mic2015.05.200es
idus.format.extent10 p.es
dc.journaltitleMicrobial Celles
dc.publication.volumen2es
dc.publication.issue5es
dc.publication.initialPage139es
dc.publication.endPage149es
dc.contributor.funderJunta de Andalucía

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional