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Expression of a neu/c-erbB-2-like product in neuroendocrine cells of mammals

Opened Access Expression of a neu/c-erbB-2-like product in neuroendocrine cells of mammals
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Autor: Martín-Lacave, Inés
Utrilla Alcolea, José Carmelo
Departamento: Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica
Fecha: 2000-01-01
Tipo de documento: Artículo
Resumen: The neulc-erbB-2 oncogen encodes a 185 kDa protein closely homologous to the epidermal growth factor receptor. The protein product (p185) is a glycoprotein with an external domain and an internal domain with tyrosine kinase activity. Amplification and/or overexpression of p185 is related to several human adenocarcinomas. Subsequent studies demonstrated its presence in certain neuroendocrine (NE) neoplasms, including phaeochromocytomas. insulinomas and medullary thyroid carcinomas. However, relatively little is known about its role in normal cell growth regulation and development. Therefore, our objetive was to determine whether neulc-erbB-2 was expressed in normal NE tissues of different mammals, specially in humans, as it was in their neoplasms. We have examined by immunohistochemistry different endocrine glands (thyroid, pancreas, suprarrenal and hypophysis) and the small intestine of human beings, rats and guinea pigs, using two polyclonal antibodies raised against the intracytopla...
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Tamaño: 747.8Kb
Formato: PDF

URI: http://hdl.handle.net/11441/59870

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