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5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

 

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Opened Access 5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
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Author: Orta Vázquez, Manuel Luis
Calderón Montaño, José Manuel
Domínguez García, Inmaculada
Pastor Carrillo, Nuria María
Burgos Morón, Estefanía
López Lázaro, Miguel
Cortés, Felipe
Mateos Cordero, Santiago
Helleday, Thomas
Department: Universidad de Sevilla. Departamento de Biología Celular
Universidad de Sevilla. Departamento de Farmacología
Date: 2013
Published in: Nucleic Acids Research, 41 (11), 5827-5836.
Document type: Article
Abstract: 5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological diseases and works by being incorporated into DNA and trapping DNMT. It is unclear what DNA lesions are caused by 5-azadC a...
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Cite: Orta Vázquez, M.L., Calderón Montaño, J.M., Domínguez García, I., Pastor Carrillo, N.M., Burgos Morón, E., López Lázaro, M.,...,Helleday, T. (2013). 5-Aza-20-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair. Nucleic Acids Research, 41 (11), 5827-5836.
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URI: http://hdl.handle.net/11441/58754

DOI: http://dx.doi.org/10.1093/nar/gkt270

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