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Pattern of degeneration of the rat inferior olivary complex after the early postnatal axotomy of the olivocerebellar projection

Opened Access Pattern of degeneration of the rat inferior olivary complex after the early postnatal axotomy of the olivocerebellar projection
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Autor: Armengol Butrón de Mújica, José Ángel
López-Roman, A.
Departamento: Universidad de Sevilla. Departamento de Anatomía y Embriología
Fecha: 1996-04-24
Publicado en: Histology and Histopathology, 11 (2), 379-388.
Tipo de documento: Artículo
Resumen: Neuronal death of inferior olivary neurons after early axotomy of the olivocerebellar tract was studied in newborn (Pl) hemicerebellectomized rats during the first six days after lesion. The degeneration of the inferior olive showed a topographic pattem from one (P2) to six days after axotomy (P7), after which this complex had almost completely disappeared. The first degenerative changes were observed in the principal olive (P2), while the media1 accessory olive was the later-degenerated area (P5). The analysis of these degenerative changes provides a reference for future experimental studies. Furthermore, the topographic study of the degenerative process demonstrated that: i) the most vulnerable neurons were dorsolaterally located, whereas the most resistant ones occupied the media1 aspect of the inferior olivary complex, ii) the comparison between the topographical arrangement of the inferior olivary neurons according to their birth dates, and the rate of degenerative changes obs...
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Formato: PDF

URI: http://hdl.handle.net/11441/57044

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