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dc.creatorKei Yip, Pinges
dc.creatorCarrillo Jiménez, Alejandroes
dc.creatorKing, Paules
dc.creatorVilalta, Annaes
dc.creatorVenero Recio, José Luises
dc.creatorBurguillos García, Miguel Ángeles
dc.date.accessioned2017-02-24T12:45:17Z
dc.date.available2017-02-24T12:45:17Z
dc.date.issued2017
dc.identifier.citationKei Yip, P., Carrillo Jiménez, A., King, P., Vilalta, A., Venero Recio, J.L. y Burguillos García, M.A. (2017). Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Scientific Reports, 7, 1-13.
dc.identifier.issn2045-2322es
dc.identifier.urihttp://hdl.handle.net/11441/54851
dc.description.abstractTraumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in Europe, indicating the need for advances in TBI treatment. Within the first 24 h after TBI, several inflammatory response factors become upregulated, including the lectin galectin-3. In this study, using a controlled cortical impact (CCI) model of head injury, we show a large increase in the expression of galectin-3 in microglia and also an increase in the released form of galectin-3 in the cerebrospinal fluid (CSF) 24 h after head injury. We report that galectin-3 can bind to TLR-4, and that administration of a neutralizing antibody against galectin-3 decreases the expression of IL-1β, IL-6, TNFα and NOS2 and promotes neuroprotection in the cortical and hippocampal cell populations after head injury. Long-term analysis demonstrated a significant neuroprotection in the cortical region in the galectin-3 knockout animals in response to TBI. These results suggest that following head trauma, released galectin-3 may act as an alarmin, binding, among other proteins, to TLR-4 and promoting inflammation and neuronal loss. Taking all together, galectin-3 emerges as a clinically relevant target for TBI therapy.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherNaturees
dc.relation.ispartofScientific Reports, 7, 1-13.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleGalectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegenerationes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica y Biología Moleculares
dc.relation.publisherversionhttp://dx.doi.org/10.1038/srep41689es
dc.identifier.doi10.1038/srep41689es
idus.format.extent14 p.es
dc.journaltitleScientific Reportses
dc.publication.volumen7es
dc.publication.initialPage1es
dc.publication.endPage13es

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