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A Study of the Robustness of the EGFR Signalling Cascade Using Continuous Membrane Systems

 

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Opened Access A Study of the Robustness of the EGFR Signalling Cascade Using Continuous Membrane Systems
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Author: Pérez Jiménez, Mario de Jesús
Romero Campero, Francisco José
Department: Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial
Date: 2005
Published in: Mechanisms, Symbols, and Models Underlying Cognition. IWINAC 2005. Lecture Notes in Computer Science, vol 3561
ISBN/ISSN: 978-3-540-26298-5
0302-9743
Document type: Chapter of Book
Abstract: Many approaches to anticancer treatment have had a limited success. A fundamental hurdle to cancer therapy is the robustness of the signalling networks involved in tumourgenesis. The complexity of net- works of biological signalling pathways is such that the development of simplifying models is essential in trying to understand the wide-ranging cellular responses they can generate. In this paper a model of the epider- mal growth factor receptor signalling cascade is developed using contin- uous membrane systems. This model is used to study the robustness of this signalling cascade which is known to play a key role in tumour cell proliferation, angiogenesis and metastasis.
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Format: PDF

URI: http://hdl.handle.net/11441/52924

DOI: 10.1007/11499220_28

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional

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