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Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model

 

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Opened Access Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
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Author: Jiménez, Sebastián
Torres, Manuel
Vizuete Chacón, María Luisa
Sánchez Varo, Raquel María
Sánchez Mejías, Elisabeth
Trujillo Estrada, Laura Isabel
Carmona Cuenca, Irene
Caballero, Cristina M.
Ruano Caballero, Diego
Gutiérrez, Antonia
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2011
Published in: Journal of Biological Chemistry, 286 (21), 18414-18425.
Document type: Article
Abstract: Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have previously characterized a big...
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Cite: Jiménez, S., Torres, M., Vizuete Chacón, M.L., Sánchez Varo, R.M., Sánchez Mejías, E., Trujillo Estrada, L.I.,...,Gutiérrez, A. (2011). Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model. Journal of Biological Chemistry, 286 (21), 18414-18425.
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URI: http://hdl.handle.net/11441/50560

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