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Evolutionary Dynamics in Gene Networks and Inference Algorithms

 

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dc.creator Aguilar Hidalgo, Daniel es
dc.creator Lemos Fernández, María del Carmen es
dc.creator Córdoba Zurita, Antonio es
dc.date.accessioned 2016-11-18T11:33:48Z
dc.date.available 2016-11-18T11:33:48Z
dc.date.issued 2015
dc.identifier.citation Aguilar Hidalgo, D., Lemos Fernández, M.d.C. y Córdoba Zurita, A. (2015). Evolutionary Dynamics in Gene Networks and Inference Algorithms. Computation, 3 (1), 99-113.
dc.identifier.issn 2079-3197 es
dc.identifier.uri http://hdl.handle.net/11441/48871
dc.description.abstract Dynamical interactions among sets of genes (and their products) regulate developmental processes and some dynamical diseases, like cancer. Gene regulatory networks (GRNs) are directed networks that define interactions (links) among different genes/proteins involved in such processes. Genetic regulation can be modified during the time course of the process, which may imply changes in the nodes activity that leads the system from a specific state to a different one at a later time (dynamics). How the GRN modifies its topology, to properly drive a developmental process, and how this regulation was acquired across evolution are questions that the evolutionary dynamics of gene networks tackles. In the present work we review important methodology in the field and highlight the combination of these methods with evolutionary algorithms. In recent years, this combination has become a powerful tool to fit models with the increasingly available experimental data. es
dc.description.sponsorship Junta de Andalucía FQM-122 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher MDPI AG es
dc.relation.ispartof Computation, 3 (1), 99-113.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Evolutionary dynamics es
dc.subject Evolutionary algorithms es
dc.subject Gene regulatory networks es
dc.title Evolutionary Dynamics in Gene Networks and Inference Algorithms es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Física de la Materia Condensada es
dc.relation.projectID FQM-122 es
dc.relation.publisherversion 10.3390/computation3010099 es
dc.identifier.doi http://dx.doi.org/10.3390/computation3010099 es
idus.format.extent 15 p. es
dc.journaltitle Computation es
dc.publication.volumen 3 es
dc.publication.issue 1 es
dc.publication.initialPage 99 es
dc.publication.endPage 113 es
dc.identifier.idus https://idus.us.es/xmlui/handle/11441/48871
dc.contributor.funder Junta de Andalucía
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