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Reduced Prepulse Inhibition as a Biomarker of Schizophrenia

Opened Access Reduced Prepulse Inhibition as a Biomarker of Schizophrenia


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Autor: Mena, Auxiliadora
Ruiz-Salas, Juan C.
Puentes, Andrea
Dorado, Inmaculada
Ruiz Veguilla, Miguel
Casa Rivas, Luis Gonzalo de La
Departamento: Universidad de Sevilla. Departamento de Psicología Experimental
Fecha: 2016-10-18
Publicado en: Frontiers in Behavioral Neurosciences, 10
Tipo de documento: Artículo
Resumen: The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is thought to reflect an alteration in dopaminergic and glutamatergic neurotransmission. In this paper we analyze whether the reported deficits are indicating a transient effect restricted to the acute phase of the disease, or if it reflects a more general biomarker or endophenotype of the disorder. To this end, we measured startle responses in the same set of thirteen schizophrenia patients with a cross-sectional design at two periods: 5 days after hospital admission and 3 months after discharge. The results showed that both startle habituation and PPI were impaired in the schizophrenia patients ...
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Cita: A. Mena, , J.C. Ruiz-Salas, , A. Puentes, , I. Dorado, , M. Ruiz-Veguilla, y L.G. De la Casa, (2016). Reduced Prepulse Inhibition as a Biomarker of Schizophrenia. Frontiers in Behavioral Neurosciences, 10
Tamaño: 285.6Kb
Formato: PDF

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DOI: 10.3389/fnbeh.2016.00202

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