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Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats

Opened Access Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats

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Autor: Tavares Vázquez, Eva
Maldonado Ordóñez, Rosario
Ojeda Murillo, María Luisa
Miñano Sánchez, Javier
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2005
Publicado en: Clinical and Diagnostic Laboratory Immunology, 12 (9), 1085-1093.
Tipo de documento: Artículo
Resumen: Gram-negative and gram-positive infections have been considered the most important causes of morbidity and mortality in patients with leukopenia following chemotherapy. However, discrimination between bacterial infections and harmless fever episodes is difficult. Because classical inflammatory signs of infection are often absent and fever is frequently the only sign of infection, the aim of this study was to assess the significance of serum interleukin-6 (IL-6), IL-10, macrophage inflammatory protein-2 (MIP-2), procalcitonin (PCT), and C-reactive protein (CRP) patterns in identifying bacterial infections during start of fever in normal and cyclophosphamide-treated (leukopenic) rats following an injection of lipopolysaccharide (LPS) or muramyl dipeptide (MDP) as a model for gram-negative and gram-positive bacterial infections. We found that, com- pared to normal rats, immunosuppressed animals exhibited significantly higher fevers and lesser production of all mediators, except ...
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Cita: Tavares Vázquez, E., Maldonado Ordóñez, R., Ojeda Murillo, M.L. y Miñano Sánchez, J. (2005). Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats. Clinical and Diagnostic Laboratory Immunology, 12 (9), 1085-1093.
Tamaño: 204.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/45793

DOI: 10.1128/CDLI.12.9.1085–1093.2005

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