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Metabolic syndrome and selenium in fetal programming: gender differences

Opened Access Metabolic syndrome and selenium in fetal programming: gender differences

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Autor: Ojeda Murillo, María Luisa
Nogales Bueno, Fátima
Muñoz del Valle, Paulina Encarnación
Díaz Castro, Javier
Murillo Taravillo, María Luisa
Carreras Sánchez, Olimpia
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2016
Publicado en: Food and Function, 7, 3031-3038.
Tipo de documento: Artículo
Resumen: Objectives: Since Selenium (Se) forms part of glutathione peroxidase (GPx), which appears to have a dual role in Metabolic Syndrome (MS), this study evaluates the implication of Se in the transmission of this pathology to the progeny. Methods: Se body distribution, glucose, triglycerides, cholesterol, insulin and metabolic hormones [glucagon, leptin, gastric inhibitory polypeptide (GIP), and triiodothyronine (T3)], growth factors, receptor activator of nuclear factor kappa-B ligand (RANK-L) and osteopontin, as well as oxidative hepatic balance in the offspring of dams exposed to a fructose-rich diet (65%) with normal Se content (0.01 ppm) during gestation and lactation, were measured according to sex. Results: Fructose pups had lower body weight; however, male pups had a lower body mass index and growth indicators in serum. Fructose pups, especially females, had lower levels of serum insulin and HOMA-IR. With regard to Se homeostasis, fructose pups presented a depletion of Se...
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Cita: Ojeda Murillo, M.L., Nogales Bueno, F., Muñoz del Valle, P., Díaz Castro, J., Murillo Taravillo, M.L. y Carreras Sánchez, O. (2016). Metabolic syndrome and selenium in fetal programming: gender differences. Food and Function, 7, 3031-3038.
Tamaño: 1.160Mb
Formato: PDF

URI: http://hdl.handle.net/11441/45391

DOI: 10.1039/C6FO00595K

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