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“Sulfolefin”: a mixed sulfinamido-olefin ligand in enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones

Opened Access “Sulfolefin”: a mixed sulfinamido-olefin ligand in enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones

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Autor: Valdivia Giménez, Victoria Esther
Fernández Fernández, Inmaculada
Khiar, N.
Departamento: Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica
Fecha: 2014
Publicado en: Organic and Biomolecular Chemistry, 12 (8), 1211-1214.
Tipo de documento: Artículo
Resumen: Performing catalytic enantioselective carbon-carbon bond forming reactions, especially for the synthesis of tertiary carbinols, is one of the most challenging goals in modern asymmetric synthesis. Herein, we report an efficient enantioselective catalytic approach for the 1,2-addition of arylboronic acids to trifluoromethyl ketones affording tertiary trifluoromethyl-substituted alcohols with high yields and good enantioselectivities. The reported process uses as a catalyst precursor the shelf stable sulfinamido-olefin ligand 1, "sulfolefin", obtained on a multigram scale and in one step from a sugar derived sulfinate ester.
Cita: Valdivia Giménez, V.E., Fernández Fernández, I. y Khiar, N. (2014). “Sulfolefin”: a mixed sulfinamido-olefin ligand in enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones. Organic and Biomolecular Chemistry, 12 (8), 1211-1214.
Tamaño: 341.1Kb
Formato: PDF

URI: http://hdl.handle.net/11441/42758

DOI: http://dx.doi.org/10.1039/c3ob41888j

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