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Reduction-sensitive functionalized copolyurethanes for biomedical applications

Opened Access Reduction-sensitive functionalized copolyurethanes for biomedical applications

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Autor: Ferris, Cristina
Paz, M. Violante de
Aguilar de Leyva, Ángela
Caraballo, Isidoro
Galbis Pérez, Juan Antonio
Departamento: Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica
Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica
Fecha: 2014
Publicado en: Polymer Chemistry, 5 (7), 2370-2381.
Tipo de documento: Artículo
Resumen: In the present paper we combine functionalization and biodegradation in the rational design of polymers that can be used as carrier systems for drug delivery in the colon. Functionalization of new polyurethanes (PUs) was achieved by thiol–ene coupling reactions, a simple and straightforward procedure included among the so-called click reactions, which are currently accepted as one of the most powerful tools in organic chemistry. Enhancement of the degradability of the new materials by the introduction of disulfide linkages into the polymer backbone has led to a new group of stimulusresponsive sugar-based polyurethanes able to be degraded by tripeptide glutathione under physiological conditions. Atomic Force Microscopy (AFM) on solid-supported multilayered dry polymer films— prepared by spin-coating from dimethylsulfoxide solutions—was used to study the morphology of the polymers and the degradation process in reductive environments. Matrix systems containing polymers selecte...
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Cita: Ferris, C., Paz, M.V.d., Aguilar de Leyva, Á., Caraballo, I. y Galbis Pérez, J.A. (2014). Reduction-sensitive functionalized copolyurethanes for biomedical applications. Polymer Chemistry, 5 (7), 2370-2381.
Tamaño: 812.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/42290

DOI: http://dx.doi.org/10.1039/c3py01572f

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