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The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

Opened Access The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

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Autor: Gallardo, Elena
Madrona, Andrés
Palma Valdés, Rocío
Trujillo, Mariana
Espartero, José Luis
Santiago Pavón, Martiniano
Departamento: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Fecha: 2014
Publicado en: RSC Advances, 4 (105), 61086-61091.
Tipo de documento: Artículo
Resumen: Hydroxytyrosol is a well-known phenolic compound with antioxidant properties that is found in virgin olive oil. Studies have shown that virgin olive oil has neuroprotective effects in rats; thus the purpose of the present study was to investigate the neuroprotective effect of hydroxytyrosol in rats. Additionally, this study aimed to investigate the neuroprotective potential of a homologous series of compounds with better lipophilic profiles in order to increase the assortment of compounds with a putative effect against Parkinson's disease (PD). In this context, the inhibition of catechol-O-methyl transferase (COMT) activity by hydroxytyrosol, nitrohydroxytyrosol, nitrohydroxytyrosol acetate and ethyl nitrohydroxytyrosol ether was investigated by measuring intracellular dopamine and its metabolite levels in the corpus striatum by high performance liquid chromatography (HPLC) with electrochemical detection. The animals received an acute (single dose; 20 mg kg-1; i.p.) or chronic (one daily...
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Cita: Gallardo, E., Madrona, A., Palma Valdés, R., Trujillo, M., Espartero, J.L. y Santiago Pavón, M. (2014). The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue. RSC Advances, 4 (105), 61086-61091.
Tamaño: 357.2Kb
Formato: PDF

URI: http://hdl.handle.net/11441/41640

DOI: http://dx.doi.org/10.1039/c4ra09872b

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