Repositorio de producción científica de la Universidad de Sevilla

Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysis

Opened Access Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysis

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Granero, Luis
Santiago Pavón, Martiniano
Cano, Josefina
Machado, Alberto
Peris, José Esteban
Departamento: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Fecha: 1995
Publicado en: Antimicrobial Agents and Chemotherapy, 39 (12), 2728-2731.
Tipo de documento: Artículo
Resumen: In vivo microdialysis was used to estimate the extracellular concentrations of ceftazidime and ceftriaxone, two expanded-spectrum cephalosporins commonly used in the treatment of bacterial meningitis, in two brain regions (the right corpus striatum and the left lateral ventricle) of awake, freely moving rats. Antibiotics were administered by constant intravenous infusion at 18 mg/h until steady-state levels were reached. Ceftriaxone levels measured at the steady state in the extracellular space of the corpus striatum (0.80 ± 0.17 J.tg/ml) were statistically equivalent to those obtained in the cerebrospinal fluid of the lateral ventricle (0.71 ± 0.15 J.tg/ml). The ratios of these levels in the brain to the steady-state levels in plasma were 0.5 ± 0.1% for both regions. The postinfusion concentrations of ceftriaxone in the brain declined monoexponentially, with an elimination half-life similar to that obtained in plasma. However, the mean antibiotic concentration of ceftazidime in the s...
[Ver más]
Cita: Granero, L., Santiago Pavón, M., Cano, J., Machado, A. y Peris, J.E. (1995). Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysis. Antimicrobial Agents and Chemotherapy, 39 (12), 2728-2731.
Tamaño: 163.8Kb
Formato: PDF

URI: http://hdl.handle.net/11441/41638

DOI: 10.1128/AAC.39.12.2728

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones