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Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence

 

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dc.creator Machado Quintana, Alberto es
dc.creator Herrera Carmona, Antonio José es
dc.creator Venero Recio, José Luis es
dc.creator Santiago Pavón, Martiniano es
dc.creator Martínez de Pablos, Rocío es
dc.creator Villarán, Ruth es
dc.creator Espinosa Oliva, Ana María es
dc.creator Argüelles, Sandro es
dc.creator Sarmiento, M. es
dc.creator Delgado Cortés, M.J. es
dc.creator Mauricio, R. es
dc.creator Cano, Josefina es
dc.date.accessioned 2016-05-25T11:09:34Z
dc.date.available 2016-05-25T11:09:34Z
dc.date.issued 2011
dc.identifier.citation Machado de la Quintana, A., Herrera Carmona, A.J., Venero Recio, J.L., Santiago Pavón, M., Martínez de Pablos, R., Villarán, R.,...,Cano, J. (2011). Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence. Parkinson's Disease, 1-11.
dc.identifier.issn 2042-0080 es
dc.identifier.uri http://hdl.handle.net/11441/41595
dc.description.abstract Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by different insults; different peripheral inflammations have been used, such as IL-1β and the ulcerative colitis model, as well as insults to the dopaminergic system such as 6-hydroxydopamine or lipopolysaccharide. In all cases, an increased loss of dopaminergic neurons was described; inflammation in the substantia nigra increased, displaying a great activation of microglia along with an increase in the production of cytokines such as IL-1βand TNF-α. Increased permeability or disruption of the BBB, with overexpression of the ICAM-1 adhesion molecule and infiltration of circulating monocytes into the substantia nigra, is also involved, since the depletion of circulating monocytes prevents the effects of peripheral inflammation. Data are reviewed in relation to epidemiological studies of PD es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Hindawi Publishing Corporation es
dc.relation.ispartof Parkinson's Disease, 1-11.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular es
dc.relation.publisherversion 10.4061/2011/393769 es
dc.identifier.doi http://dx.doi.org/10.4061/2011/393769 es
idus.format.extent 11 p. es
dc.journaltitle Parkinson's Disease es
dc.publication.initialPage 1 es
dc.publication.endPage 11 es
dc.identifier.idus https://idus.us.es/xmlui/handle/11441/41595
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