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Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation

 

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Opened Access Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
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Author: Burguillos García, Miguel Ángel
Svensson, Martina
Schulte, Tim
Boza Serrano, Antonio
García Quintanilla, Alberto
Kavanagh, Edel T.
Santiago Pavón, Martiniano
Viceconte, Nikenza
Oliva Martín, María José
Osman, Ahmed Mohamed
Salomonsson, Emma
Amar, Lahouari
Persson, Annette
Blomgren, Klas
Achour, Adnane
Englund, Elisabet
Leffler, Hakon
Venero Recio, José Luis
Joseph, Bertrand
Deierborg, Tomas
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2015
Published in: Cell Reports, 10 (9), 1626-1639.
Document type: Article
Abstract: Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia’s inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent- TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain
Cite: Burguillos García, M.Á., Svensson, M., Schulte, T., Boza Serrano, A., García Quintanilla, A., Kavanagh, E.T.,...,Deierborg, T. (2015). Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation. Cell Reports, 10 (9), 1626-1639.
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URI: http://hdl.handle.net/11441/41543

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