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Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia

Opened Access Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia

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Autor: Kavanagh, Edel T.
Rodhe, Johanna
Burguillos García, Miguel Ángel
Venero Recio, José Luis
Joseph, Bertrand
Departamento: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Fecha: 2014
Publicado en: Cell death and disease, 5 (12), 1-9.
Tipo de documento: Artículo
Resumen: The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-3, commonly known to have executioner role for apoptosis, was uncovered in the microglia activation process. A central question emerging from this finding is what prevents caspase-3 during the microglia activation from killing those cells? Caspase-3 activation occurs as a two-step process, where the zymogen is first cleaved by upstream caspases, such as caspase-8, to form intermediate, yet still active, p19/p12 complex; thereafter, autocatalytic processing generates the fully mature p17/p12 form of the enzyme. Here, we show that the induction of cellular inhibitor of apoptosis protein 2 (cIAP2) expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit and is responsible for restraining...
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Cita: Kavanagh, E.T., Rodhe, J., Burguillos García, M.Á., Venero Recio, J.L. y Joseph, B. (2014). Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. Cell death and disease, 5 (12), 1-9.
Tamaño: 933.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/41542

DOI: http://dx.doi.org/10.1038/cddis.2014.514

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