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Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study

Opened Access Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study

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Autor: Abilés, Jimena
Pérez de la Cruz, Antonio Jesús
Castaño, José García
Rodríguez Elvira, Manuel
Aguayo, Eduardo
Moreno Torres, Rosario
Llopis, Juan Emilio
Aranda, Pilar
Argüelles, Sandro
Ayala Gómez, Antonio
Machado de la Quintana, Alberto
Planells, Elena María
Departamento: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Fecha: 2006
Publicado en: Critical Care, 10 (5), 1-9.
Tipo de documento: Artículo
Resumen: Critically ill patients suffer from oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Although ROS/RNS are constantly produced under normal circumstances, critical illness can drastically increase their production. These patients have reduced plasma and intracellular levels of antioxidants and free electron scavengers or cofactors, and decreased activity of the enzymatic system involved in ROS detoxification. The prooxidant/ antioxidant balance is of functional relevance during critical illness because it is involved in the pathogenesis of multiple organ failure. In this study the objective was to evaluate the relation between oxidative stress in critically ill patients and antioxidant vitamin intake and severity of illness. Methods Spectrophotometry was used to measure in plasma the total antioxidant capacity and levels of lipid peroxide, carbonyl group, total protein, bilirubin and uric acid at two time points: at intensive...
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Cita: Abilés, J., Pérez de la Cruz, A.J., Castaño, J.G., Rodríguez Elvira, M., Aguayo, E., Moreno Torres, R.,...,Planells, E.M. (2006). Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study. Critical Care, 10 (5), 1-9.
Tamaño: 434.8Kb
Formato: PDF

URI: http://hdl.handle.net/11441/41541

DOI: http://dx.doi.org/10.1186/cc5068

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