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Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

 

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Opened Access Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
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Author: Viceconte, Nikenza
Burguillos García, Miguel Ángel
Herrera Carmona, Antonio José
Martínez de Pablos, Rocío
Joseph, Bertrand
Venero Recio, José Luis
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2015
Published in: Journal of Neuroinflammation, 12 (1), 1-15.
Document type: Article
Abstract: Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was found in reactive microgli...
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Cite: Viceconte, N., Burguillos García, M.Á., Herrera Carmona, A.J., Martínez de Pablos, R., Joseph, B. y Venero Recio, J.L. (2015). Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism. Journal of Neuroinflammation, 12 (1), 1-15.
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URI: http://hdl.handle.net/11441/41536

DOI: http://dx.doi.org/10.1186/s12974-014-0228-x

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