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Leptin Receptor Is Up-regulated in Inflamed Human Dental Pulp

Opened Access Leptin Receptor Is Up-regulated in Inflamed Human Dental Pulp

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Autor: Martín González, Jenifer
Pérez-Pérez, Antonio
Sánchez-Jiménez, Flora
Carmona-Fernández, Antonio
Torres-Lagares, Daniel
Sánchez-Margalet, Victor
Segura-Egea, Juan J
Departamento: Universidad de Sevilla. Departamento de Estomatología
Fecha: 2013
Publicado en: Journal of Endodontics, 39 (12), 1567-1571
Tipo de documento: Artículo
Resumen: After leptin receptor (LEPR) identification in hematopoietic, immune system, and other tissues, a role for leptin regulating inflammation and immune response has been accepted. This study aims to describe the possible expression of LEPR in healthy human dental pulp and to compare it with LEPR expression in inflamed human dental pulp. Methods: Twenty-one pulp samples were obtained from freshly extracted caries-free and restoration-free human third molars. In 7 third molars (inflamed pulp group), inflammation was experimentally induced before extraction. Pulp samples were processed, and LEPR expression was determined by quantitative real-time polymerase chain reaction, and the amount of LEPR protein was analyzed by immunoblot. Results: All healthy and inflamed dental pulp samples expressed LEPR. Western blot analysis of human dental pulp revealed the presence of a protein with an apparent molecular weight of approximately 120 kDa, which corresponds to the estimated molecular weight of...
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Formato: PDF

LeptinReceptorIsUpregulated

URI: http://hdl.handle.net/11441/41347

DOI: http://dx.doi.org/10.1016/j.joen.2013.08.014

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