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Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication

Opened Access Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication


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Autor: Ma, Li-Jun
Ibrahim, Ashraf S.
Skory, Christopher
Grabherr, Manfred G.
Burger, Gertraud
Butler, Margi
Elias, Marek
Idnurm, Alexander
Lang, B. Franz
Sone, Teruo
Abe, Ayumi
Calvo, Sarah E.
Corrochano Peláez, Luis María
Engels, Reinhard
Jianmin Fu
Hansberg, Wihelm
Jung-Mi Kim
Kodira, Chinnappa D.
Koehrsen, Michael J.
Bo Liu
Miranda Saavedra, Diego
O’Leary, Sinead
Ortiz Castellanos, Lucila
Poulter, Russell
Rodriguez Romero, Julio
Ruiz Herrera, José
Yao-Qing Shen
Qiandong Zeng
Galagan, James
Birren, Bruce W.
Cuomo, Christina A.
Wickes, Brian L.
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2009
Publicado en: PLoS Genetics, 5,  e1000549
Tipo de documento: Artículo
Resumen: Rhizopus oryzae is the primary cause of mucormycosis, an emerging, life-threatening infection characterized by rapid angioinvasive growth with an overall mortality rate that exceeds 50%. As a representative of the paraphyletic basal group of the fungal kingdom called ‘‘zygomycetes,’’ R. oryzae is also used as a model to study fungal evolution. Here we report the genome sequence of R. oryzae strain 99–880, isolated from a fatal case of mucormycosis. The highly repetitive 45.3 Mb genome assembly contains abundant transposable elements (TEs), comprising approximately 20% of the genome. We predicted 13,895 protein-coding genes not overlapping TEs, many of which are paralogous gene pairs. The order and genomic arrangement of the duplicated gene pairs and their common phylogenetic origin provide evidence for an ancestral whole-genome duplication (WGD) event. The WGD resulted in the duplication of nearly all subunits of the protein complexes associated with respiratory electron transport c...
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