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Precursors of chondroitin sulfate proteoglycan are segregated within a subcompartment of the chondrocyte endoplasmic reticulum

Opened Access Precursors of chondroitin sulfate proteoglycan are segregated within a subcompartment of the chondrocyte endoplasmic reticulum
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Autor: Velasco López, Ángel
Vertel, Barbara M.
LaFrance, Sherrie
Waiters, Linda
Kaczman-Daniel, Karen
Departamento: Universidad de Sevilla. Departamento de Biología Celular
Fecha: 1989
Publicado en: Journal of Cell Biology, 109(4 Pt 1):1827-36
Tipo de documento: Artículo
Resumen: Immunocytochemical methods were used at the levels of light and electron microscopy to examine the intracellular compartments of chondrocytes involved in extracellular matrix biosynthesis. The results of our studies provide morphological evidence for the compartmentalization of secretory proteins in the ER. Precursors of the large chondroitin sulfate proteoglycan (CSPG), the major proteoglycan species produced by chondrocytes, were present in the Golgi complex. In addition, CSPG precursors were localized in specialized regions of the ER. Link protein, a separate gene product which functions to stabilize extracellular aggregates of CSPG monomers with hyaluronic acid, was segregated similarly. In contrast, type II procollagen, another major secretory molecule produced by chondrocytes, was found homogeneously distributed throughout the ER. The CSPG precursor-containing ER compartment exhibits a variable tubulo-vesicular morphology but is invariably recognized as an electronlucent, smooth...
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Formato: PDF

URI: http://hdl.handle.net/11441/40572

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