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Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II

Opened Access Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II

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Autor: Velasco López, Ángel
Hendrick, Linda
Moremen, Kelly W.
Tulsiani, D. R. P.
Touster, Oscar
Farquhar, Marilyn Gist
Departamento: Universidad de Sevilla. Departamento de Biología Celular
Fecha: 1993
Publicado en: Journal of Cell Biology, 122(1):39-51
Tipo de documento: Artículo
Resumen: alpha-mannosidases I and II (Man I and II) are resident enzymes of the Golgi complex involved in oligosaccharide processing during N-linked glycoprotein biosynthesis that are widely considered to be markers of the cis- and medial-Golgi compartments, respectively. We have investigated the distribution of these enzymes in several cell types by immunofluorescence and immunoelectron microscopy. Man II was most commonly found in medial- and/or trans- cisternae but showed cell type-dependent variations in intra-Golgi distribution. It was variously localized to either medial (NRK and CHO cells), both medial and trans (pancreatic acinar cells, enterocytes), or trans- (goblet cells) cisternae, or distributed across the entire Golgi stack (hepatocytes and some enterocytes). The distribution of Man I largely coincided with that of Man II in that it was detected primarily in medial- and trans-cisternae. It also showed cell type dependent variations in its intra-Golgi distribution. Man I and Man I...
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Tamaño: 7.681Mb
Formato: PDF

URI: http://hdl.handle.net/11441/40571

DOI: 10.1083/jcb.122.1.39

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