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The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles

Opened Access The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles

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Autor: Muñiz Guinea, Manuel
Nuoffer, Claude
Hauri, Hans Peter
Riezman, Howard
Departamento: Universidad de Sevilla. Departamento de Biología Celular
Fecha: 2000
Publicado en: Journal of Cell Biology,148 (5), 925-930
Tipo de documento: Artículo
Resumen: Members of the yeast p24 family, including Emp24p and Erv25p, form a heteromeric complex re- quired for the efficient transport of selected proteins from the endoplasmic reticulum (ER) to the Golgi ap- paratus. The specific functions and sites of action of this complex are unknown. We show that Emp24p is di- rectly required for efficient packaging of a lumenal cargo protein, Gas1p, into ER-derived vesicles. Emp24p and Erv25p can be directly cross-linked to Gas1p in ER-derived vesicles. Gap1p, which was not af- fected by emp24 mutation, was not cross-linked. These results suggest that the Emp24 complex acts as a cargo receptor in vesicle biogenesis from the ER
Tamaño: 203.0Kb
Formato: PDF

URI: http://hdl.handle.net/11441/40070

DOI: http://dx.doi.org/10.1083/jcb.148.5.925

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