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Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis

Opened Access Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis

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Autor: Bullon, Pedro
Cordero, Mario D.
Quiles, José L.
Morillo, J.M.
Ramirez Tortosa, Maria Carmen
Battino, Maurizio
Departamento: Universidad de Sevilla. Departamento de Estomatología
Fecha: 2011-02-24
Publicado en: Free Radical Biology & Medicine, 50(10),1336-1343
Tipo de documento: Artículo
Resumen: Oxidative stress is one of the factors that could explain the athophysiological mechanism of inflammatory conditions that occur in cardiovascular disease (CVD) and periodontitis. Such inflammatory response is often evoked by specific bacteria, as the lipopolysaccharide (LPS) of Porphyromonas gingivalis is a key factor in this process. The aim of this research was to study the role of mitochondrial dysfunction in peripheral blood mononuclear cells (PBMCs) from periodontitis patients and to evaluate the influence of LPS on fibroblasts to better understand the pathophysiology of periodontitis and its relationship with CVD. PBMCs from patients showed lower CoQ10 levels and citrate synthase activity, togetherwith high levels of ROS production. LPS-treated fibroblasts provoked increased oxidative stress and mitochondrial dysfunction by a decrease in mitochondrial protein expression, mitochondrial mass, and mitochondrial membrane potential. Our study supports the hypothesis that LPS-mediated...
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Tamaño: 669.1Kb
Formato: PDF

URI: http://hdl.handle.net/11441/39916

DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2011.02.018

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