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Role of vascular mechanisms involved in the acute gastric mucosal injury induced by droxicam and piroxicam in rats

Opened Access Role of vascular mechanisms involved in the acute gastric mucosal injury induced by droxicam and piroxicam in rats

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Autor: Martín Calero, María José
Alarcón de la Lastra Romero, Catalina
Ávila, J. R.
Motilva Sánchez, Virginia
Luque, I.
Esteban, José Manuel
Herrerías Gutiérrez, Juan Manuel
Departamento: Universidad de Sevilla. Departamento de Farmacología
Fecha: 1997
Publicado en: Pharmaceutical Science, 3 (3), 137-141
Tipo de documento: Artículo
Resumen: We describe the formation of severe gastric erosions produced in fasted rats by intragastric administration of droxicam and its active species piroxicam, non-steroidal anti-inflammatory drugs of the oxicam group. The time course of gastric damage and the possible role of mucus secretion, changes of gastric vascular permeability, and neutrophil activation in the development of droxicam- and piroxicam-induced astric lesions, were also investigated. Both drugs dose-dependently (1-25-20 mg kg - ) caused acute gastric haemorrhagic erosions in the rat. These lesions were significantly greater with piroxicam treatment 6 h after dosing. Only the lower doses of droxicam and piroxicam (1.25 mg kg-') induced a significant increase of mucus gel production at different times (3 and 6 h). However, there was no increase in the concentration of its components. Oral pretreatment of the animals with either agent did not induce any changes on the values of mucosal vascular permeability. In co...
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Tamaño: 464Kb
Formato: PDF

URI: http://hdl.handle.net/11441/39150

DOI: http://dx.doi.org/10.1111/j.2042-7158.1997.tb00238.x

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