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The Discovery of Initial Fluxes of Metabolic P Systems

Opened Access The Discovery of Initial Fluxes of Metabolic P Systems
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Autor: Pagliarini, Roberto
Manca, Vincenzo
Fecha: 2009
Publicado en: Proceedings of the Seventh Brainstorming Week on Membrane Computing, vol.II, 115-126. Sevilla, E.T.S. de Ingeniería Informática, 2-6 de Febrero, 2009
ISBN/ISSN: 9788461328369
Tipo de documento: Ponencia
Resumen: A central issue in systems biology is the study of efficient methods to infer fluxes of biological reactions starting from experimental data. Among the different techniques proposed in the last years, in the theory of Metabolic P systems Log-Gain principles have been introduced, which prove to be helpful for deducing biological fluxes from temporal series of observed dynamics. However, crucial tasks remain to be performed for a complete suitable application of these principles. In particular the algebraic systems introduced by the Log-Gain principles require the knowledge of the initial fluxes associated with a set of biochemical reactions. In this paper we propose an algorithm for estimating initial fluxes, which is tested in two case studies.
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