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Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats

Opened Access Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats

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Autor: Vázquez Castilla, Sara
Puerta Vázquez-Zafra, Rocío de la
García Giménez, María Dolores
Guillén Bejarano, Rafael
Fernández Arche, María de los Ángeles
Departamento: Universidad de Sevilla. Departamento de Farmacología
Fecha: 2013
Publicado en: International Journal of Molecular Sciences, 14, 21227-21239
Tipo de documento: Artículo
Resumen: We have previously shown that the Andalusian-cultivated Asparagus officinalis L. “triguero” variety produces hypocholesterolemic and hepatoprotective effects on rats. This asparagus is a rich source of phytochemicals although we hypothesized there would be some of them more involved in these functional properties. Thus, we aimed to study the effects of asparagus (500 mg/kg body weight (bw)/day) and their partially purified fractions in flavonoids (50 mg/kg bw/day), saponins (5 mg/kg bw/day) and dietary fiber (500 mg/kg bw/day) on oxidative status and on lipid profile in rats fed a cholesterol-rich diet. After 5 weeks treatment, plasma lipid values, hepatic enzyme activities and liver malondialdehyde (MDA) concentrations were measured. With the exception of the saponin fraction (SF), the administration of lyophilized asparagus (LA), fiber fraction (FF), and flavonoid fraction (FVF) to hypercholesterolemic rats produced a significant hypolipidemic effect compare to a high-cholesterol...
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Tamaño: 264.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/38802

DOI: http://dx.doi.org/10.3390/ijms141121227

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