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Four main virotypes among extended-spectrum-β-lactamase-producing isolates of Escherichia coli O25b:H4-B2-ST131: bacterial, epidemiological, and clinical characteristics

Opened Access Four main virotypes among extended-spectrum-β-lactamase-producing isolates of Escherichia coli O25b:H4-B2-ST131: bacterial, epidemiological, and clinical characteristics

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Autor: Blanco, Jorge
Mora, Azucena
Mamani, Rosalia
López, Cecilia
Blanco, Miguel
Dahbi, Ghizlane
Herrera, Alexandra
Marzoa, Juan
Fernández, Val
Cruz, Fernando de la
Martínez-Martínez, Luis
Alonso, María Pilar
Nicolas-Chanoine, Marie-Hélène
Johnson, James R.
Johnston, Brian
López Cerero, Lorena
Pascual, Álvaro
Rodríguez-Baño, Jesús
Departamento: Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Microbiología
Fecha: 2013-10
Tipo de documento: Artículo
Resumen: A total of 1,021 extended-spectrum- -lactamase-producing Escherichia coli (ESBLEC) isolates obtained in 2006 during a Spanish national survey conducted in 44 hospitals were analyzed for the presence of the O25b:H4-B2-ST131 (sequence type 131) clonal group. Overall, 195 (19%) O25b-ST131 isolates were detected, with prevalence rates ranging from 0% to 52% per hospital. Molecular characterization of 130 representative O25b-ST131 isolates showed that 96 (74%) were positive for CTX-M-15, 15 (12%) for CTX-M-14, 9 (7%) for SHV-12, 6 (5%) for CTX-M-9, 5 (4%) for CTX-M-32, and 1 (0.7%) each for CTX-M-3 and the new ESBL enzyme CTX-M-103. The 130 O25b-ST131 isolates exhibited relatively high virulence scores (mean, 14.4 virulence genes). Although the virulence profiles of the O25b-ST131 isolates were fairly homogeneous, they could be classified into four main virotypes based on the presence or absence of four distinctive virulence genes: virotypes A (22%) (afa FM955459 positive, iroN neg...
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Cita: Blanco, J., Mora, A., Mamani, R., López, C., Blanco, M., Dahbi, G.,...,Rodríguez-Baño, J. (2013). Four main virotypes among extended-spectrum-β-lactamase-producing isolates of Escherichia coli O25b:H4-B2-ST131: bacterial, epidemiological, and clinical characteristics.
Tamaño: 700.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/38447

DOI: http://dx.doi.org/10.1128/JCM.01555-13

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