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Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice

 

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Opened Access Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice
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Author: Gutiérrez Pozo, Gabriel
Kong, Elizabeth
Sabbagh, Yves
Brown, Nelson E.
Lee, Jong-Seo
Demay, Marie B.
Thomas, David M.
Hinds, Philip W.
Department: Universidad de Sevilla. Departamento de Genética
Date: 2008
Published in: Proceedings of the National Academy of Sciences of the United States of America, 105, 18402-18407
Document type: Article
Abstract: We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2-dependent, bone-specific genes in cultured cells. We now show that pRb also plays a role early in osteogenesis, and that in primary RB1-/- calvarial cell...
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URI: http://hdl.handle.net/11441/36712

DOI: http://dx.doi.org/10.1073/pnas.0805925105

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