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Virulence profiles of bacteremic extended-spectrum ß-lactamase-producing Escherichia coli: association with epidemiological and clinical features

Opened Access Virulence profiles of bacteremic extended-spectrum ß-lactamase-producing Escherichia coli: association with epidemiological and clinical features

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Autor: Rodríguez-Baño, Jesús
Mingorance, Jesús
Fernández-Romero, Natalia
Serrano, Lara
López Cerero, Lorena
Pascual Hernández, Álvaro
Departamento: Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Microbiología
Fecha: 2012
Publicado en: PLoS ONE,7(9),e44238
Tipo de documento: Artículo
Resumen: There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused by extended-spectrum b-lactamase-producing Escherichia coli (ESBLEC). A prospective multicenter Spanish cohort including 191 cases of BSI due to ESBLEC was studied. Phylogroups and 25 VF genes were investigated by PCR. ESBLEC were classified into clusters according to their virulence profiles. The association of phylogropus, VF, and clusters with epidemiological features were studied using multivariate analysis. Overall, 57.6%, 26.7%, and 15.7% of isolates belonged to A/B1, D and B2 phylogroups, respectively. By multivariate analysis (adjusted OR [95% CI]), virulence cluster C2 was independently associated with urinary tract source (5.05 [0.96–25.48]); cluster C4 with sources other than urinary of biliary tract (2.89 [1.05– 7.93]), and cluster C5 with BSI in non-predisposed patients (2.80 [0.99–7.93]). Isolates producing CTX-M-9 group ESBLs and from phylog...
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Tamaño: 261.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/34535

DOI: 10.1371/journal.pone.0044238

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