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Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism

Opened Access Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism

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Autor: Sanz, Catalina
Rodríguez Romero, Julio
Idnurm, Alexander
Christie, John M.
Heitman, Joseph
Corrochano Peláez, Luis María
Eslava, Arturo P.
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2009
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, 106(17), 7095-7100
Tipo de documento: Artículo
Resumen: The fungus Phycomyces blakesleeanus reacts to environmental signals, including light, gravity, touch, and the presence of nearby objects, by changing the speed and direction of growth of its fruiting body (sporangiophore). Phototropism, growth toward light, shares many features in fungi and plants but the molecular mechanisms remain to be fully elucidated. Phycomyces mutants with altered phototropism were isolated ≈40 years ago and found to have mutations in the mad genes. All of the responses to light in Phycomyces require the products of the madA and madB genes. We showed that madA encodes a protein similar to the Neurospora blue-light photoreceptor, zinc-finger protein WC-1. We show here that madB encodes a protein similar to the Neurospora zinc-finger protein WC-2. MADA and MADB interact to form a complex in yeast 2-hybrid assays and when coexpressed in E. coli, providing evidence that phototropism and other responses to light are mediated by a photoresponsive transcription factor...
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Tamaño: 664.2Kb
Formato: PDF

URI: http://hdl.handle.net/11441/29243

DOI: http://dx.doi.org/10.1073/pnas.0900879106

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