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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

 

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Opened Access Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
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Author: Luna Varo, Rosa María
Japón Rodríguez, Miguel Ángel
Sáez, Carmen
Domínguez Sánchez, María Salud
Aguilera López, Andrés
Department: Universidad de Sevilla. Departamento de Genética
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)
Date: 2011
Published in: BMC Cancer, 77 (11)
Document type: Article
Abstract: One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.
Cite: Luna Varo, R.M., Japón Rodríguez, M.Á., Sáez, C., Domínguez Sánchez, M.S. y Aguilera López, A. (2011). Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer, 77 (11)
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URI: http://hdl.handle.net/11441/23048

DOI: https://doi.org/10.1186/1471-2407-11-77

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