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Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity

Opened Access Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity
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Autor: Andriantsitohaina, Ramaroson
Mingorance Gutiérrez, María del Carmen
Herrera, María Dolores
Álvarez de Sotomayor Paz, María
Duluc, Lucie
Chalopin, Matthieu
Simard, Gilles
Ducluzeau, Pierre-Henri
Departamento: Universidad de Sevilla. Departamento de Farmacología
Fecha: 2012
Publicado en: PLoS ONE, 7(3)
Tipo de documento: Artículo
Resumen: Aims: Obesity is a primary contributor to acquired insulin resistance leading to the development of type 2 diabetes and cardiovascular alterations. The carnitine derivate, propionyl-L-carnitine (PLC), plays a key role in energy control. Our aim was to evaluate metabolic and cardiovascular effects of PLC in diet-induced obese mice. Methods: C57BL/6 mice were fed a high-fat diet for 9 weeks and then divided into two groups, receiving either free- (vehicle-HF) or PLC-supplemented water (200 mg/kg/day) during 4 additional weeks. Standard diet-fed animals were used as lean controls (vehicle-ST). Body weight and food intake were monitored. Glucose and insulin tolerance tests were assessed, as well as the HOMAIR, the serum lipid profile, the hepatic and muscular mitochondrial activity and the tissue nitric oxide (NO) liberation. Systolic blood pressure, cardiac and endothelial functions were also evaluated. Results: Vehicle-HF displayed a greater increase of body weight compared to v...
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URI: http://hdl.handle.net/11441/23019

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