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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy

 

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Opened Access Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
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Author: Bautista Palomas, Juan Dionisio
Campo Castillo, José Antonio del
Romero Gómez, Manuel
Ranchal Illescas, Isidora
Camacho Benítez, Inés
Nuñez Hospital, David
Díaz Herrero, María del Mar
Rojas, Ángela
Maraver Zamora, Marta
Ampuero Herrojo, Javier
Figueruela, Blanca
Department: Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2012
Published in: PLoS ONE, 7 (11), e49279-1-e49279-6.
Document type: Article
Abstract: Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ammonia production in vitro. ...
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URI: http://hdl.handle.net/11441/18246

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