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Low pO2 selectively inhibits K channel activity in chemoreceptor cells of the mammalian carotid body

Opened Access Low pO2 selectively inhibits K channel activity in chemoreceptor cells of the mammalian carotid body
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Autor: López López, J.
González Montelongo, M. Carmen
Ureña López, Juan
López Barneo, José
Departamento: Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica
Fecha: 1989
Publicado en: The Journal of general physiology, 93 (5), 1001-1015.
Tipo de documento: Artículo
Resumen: The hypothesis that changes in environmental O2 tension (pO2) could affect the ionic conductances of dissociated type I cells of the carotid body was tested. Cells were subjected to whole-cell patch clamp and ionic currents were recorded in a control solution with normal pO2 (pO2 = 150 mmHg) and 3-5 min after exposure to the same solution with a lower pO2. Na and Ca currents were unaffected by lowering pO2 to 10 mmHg, however, in all cells studied (n = 42) exposure to hypoxia produced a reversible reduction of the K current. In 14 cells exposed to a pO2 of 10 mmHg peak K current amplitude decreased to 35 +/- 8% of the control value. The effect of low pO2 was independent of the internal Ca2+ concentration and was observed in the absence of internal exogenous nucleotides. Inhibition of K channel activity by hypoxia is a graded phenomenon and in the range between 70 and 120 mmHg, which includes normal pO2 values in arterial blood, it is directly correlated with pO2 levels. Low pO2 appear...
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URI: http://hdl.handle.net/11441/17805

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