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GDNF Is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after Injury of the nigrostriatal pathway

Opened Access GDNF Is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after Injury of the nigrostriatal pathway
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Autor: Hidalgo-Figueroa, María
Bonilla Jiménez, Sonia
Gutiérrez, Francisco
Pascual Bravo, Alberto
López Barneo, José
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2012
Publicado en: The Journal of Neuroscience, 32 (3), 864-872.
Tipo de documento: Artículo
Resumen: Glial cell line-derived neurotrophic factor (GDNF) is absolutely required for survival of dopaminergic (DA) nigrostriatal neurons and protect them from toxic insults. Hence, it is a promising, albeit experimental, therapy for Parkinson’s disease (PD). However, the source of striatal GDNF is not well known. GDNF seems to be normally synthesized in neurons, but numerous reports suggest GDNF production in glial cells, particularly in the injured brain. We have studied in detail striatal GDNF production in normal mouse and after damage of DA neurons with MPTP. Striatal GDNF mRNA was present in neonates but markedly increased during the first 2–3 postnatal weeks. Cellular identification of GDNF by unequivocal histochemical methods demonstrated that in normal or injured adult animals GDNF is expressed by striatal neurons and is not synthesized in significant amounts by astrocytes or microglial cells.GDNFmRNAexpression was not higher in reactive astrocytes than in normal ones. Approximately ...
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Formato: PDF

URI: http://hdl.handle.net/11441/17471

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