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Artículo
Diferencias entre pacientes institucionalizados y pacientes en atención domiciliaria en la provincia de Sevilla
(Elsevier, 2020-09)
Objetivo: Conocer las características y las diferencias clínicas entre pacientes institucionalizados y los de programas de atención domiciliaria. Diseño: Estudio observacional descriptivo transversal multicéntrico. Em ...
Artículo
Combined Effects of Exercise and Denosumab Treatment on Local Failure in Post-menopausal Osteoporosis–Insights from Bone Remodelling Simulations Accounting for Mineralisation and Damage
(Frontiers Media S.A., 2021)
Denosumab has been shown to increase bone mineral density (BMD) and reduce the fracture risk in patients with post-menopausal osteoporosis (PMO). Increase in BMD is linked with an increase in bone matrix mineralisation due ...
Artículo
Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability
(Frontiers, 2023)
Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This model is based on two major extensions of a temporal-only bone cell population model (BCPM). First, ...
Artículo
Evolution of relaxation properties of callus tissue during bone transport
(Sage, 2022-09)
Callus tissue exhibits a viscoelastic behavior that has a strong influence on the distribution of stresses and their evolution with time and, thus, it can affect tissue differentiation during distraction procedures. For ...
Artículo
Comparison of the viscoelastic properties of human abdominal and breast adipose tissue and its incidence on breast reconstruction surgery. A pilot study
(Elsevier, 2019)
Background: Breast cancer is the leading malignant tumor in women in the world. Reconstruction after mastectomy plays a key role in the physical and psychological recuperation, being the abdominal skin and adipose tissue ...
Artículo
Mechanistic PK-PD model of alendronate treatment of postmenopausal osteoporosis predicts bone site-specific response
(Frontiers Media S.A., 2022-08-17)
Alendronate is the most widely used drug for postmenopausal osteoporosis (PMO). It inhibits bone resorption, affecting osteoclasts. Pharmacokinetics (PK) and pharmacodynamics (PD) of alendronate have been widely studied, ...
Artículo
A novel algorithm to resolve lack of convergence and checkerboard instability in bone adaptation simulations using non-local averaging
(Wiley-Blackwell, 2021)
Checkerboard is a typical instability in finite element (FE) simulations of bone adaptation and topology optimization in general. It consists in a patchwork pattern with elements of alternating stiffness, producing lack ...
Artículo
Quasi-Linear Viscoelastic Model of the Articular Disc of the Temporomandibular Joint
(Springer, 2016-09)
A precise characterization of the articular disc of the temporomandibular joint (TMJ) is essential to study the masticatory biomechanics. The disc is responsible for the load distribution over the articular surface and for ...
Artículo
Are drug holidays a safe option in treatment of osteoporosis? — Insights from an in silico mechanistic PK–PD model of denosumab treatment of postmenopausal osteoporosis
(Elsevier, 2021-01)
Recent reviews by the clinical bone research community suggest caution with prescription of drug holidays for patients with postmenopausal osteoporosis (PMO) treated with denosumab for an extended period of time. Main ...
Artículo
Effect of freezing storage time on the elastic and viscous properties of the porcine TMJ disc
(Elsevier, 2017)
The correct characterisation of the articular disc of the temporomandibular joint (TMJ) is key to study the masticatory biomechanics. For the interval from extraction until testing, freezing is the most used preservation ...