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- Listar Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) por autor
Listar Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) por autor "Aguilera López, Andrés"
Mostrando ítems 1-20 de 61
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Artículo
A CDK-regulated chromatin segregase promoting chromosome replication
Chacin, Erika; Bansal, Priyanka; Reusswig, Karl-Uwe; Díaz Santín, Luis M.; Ortega Moreno, Pedro; Vizjak, Petra; Gómez González, Belén; Müller-Planitz, Felix; Aguilera López, Andrés; Pfander, Boris; Cheung, Alan C. M.; Kurat, Christoph F. (Springer Nature, 2021)The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
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Artículo
A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
García Muse, Tatiana; Galindo Díaz, U.; García Rubio, María Luisa; Martin, Julie S.; Polanowska, Jolanta; O'Reilly, N.; Aguilera López, Andrés; Boulton, Simon J. (Elsevier B.V., 2019)Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ...
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Artículo
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
Dagg, Rebecca A.; Zonderland, Gijs; Puig Lombardi, Emilia; Rossetti, Giacomo G.; Groelly, Florian J.; Barroso Ceballos, Sonia Inés; Tacconi, Eliana M. C.; Wright, Benjamin; Lockstone, Helen; Aguilera López, Andrés; Halazonetis, Thanos D.; Tarsounas, Madalena (Springer Nature, 2021)BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
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Artículo
Actin nucleators safeguard replication forks by limiting nascent strand degradation
Nieminuszczy, J.; Martin, P. R.; Broderick, R.; Krwawicz, J.; Kanellou, A.; Mocanu, C.; Bousgouni, V.; Smith, C.; Aguilera López, Andrés; Niedzwiedz, Wojciech (Oxford University Press, 2023)Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ...
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Capítulo de Libro
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast
Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Elsevier, 2021)The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...
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Artículo
Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor
Peña, Álvaro; Gewartowski, Kamil; Mroczek, Seweryn; Cuéllar, Jorge; Szykowska, Aleksandra; Prokop, Andrzej; Czarnocki-Cieciura, Mariusz; Piwowarski, Jan; Tous Rivera, Cristina; Aguilera López, Andrés; Carrascosa, José L.; Valpuesta, José María; Dziembowski, Andrzej (Wiley-Blackwell, 2012)The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...
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Artículo
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
Gómez González, Belén; Aguilera López, Andrés (Wiley-Blackwell, 2023)Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...
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Artículo
CDK targets Sae2 to control DNA-end resection and homologous recombination
Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Aguilera López, Andrés; Jackson, Stephen P. (Nature Publishing Group, 2008)DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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Artículo
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
Muñoz Galván, Sandra; López Saavedra, Ana; Jackson, Stephen P.; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Aguilera López, Andrés (Oxford University Press, 2013)While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
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Tesis Doctoral
Control genético de las deleciones entre secuencias repetidas directas en Saccaromyces cerevisiae
Prado Velasco, José Félix (1996)Los genomios de todos los organismos están constituidos por un número variable de secuencias repetidas, que pueden llegar ...
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Artículo
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
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Artículo
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019)THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
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Capítulo de Libro
Detection of DNA-RNA hybrids in vivo
García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Humana Press Inc., 2018)DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ...
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Artículo
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
Luna Varo, Rosa María; Japón Rodríguez, Miguel Ángel; Sáez, Carmen; Domínguez Sánchez, María Salud; Aguilera López, Andrés (2011)One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
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Artículo
Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange
Muñoz Galván, Sandra; Tous, Cristina; Blanco, Miguel G.; Schwartz, Erin K.; Ehmsen, Kirk T.; West, Stephen C.; Heyer, Wolf-Dietrich; Aguilera López, Andrés (2012)Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination ...
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Artículo
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
Ortega Moreno, Pedro; Mérida Cerro, José Antonio; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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Artículo
DNA-RNA hybrids: The risks of DNA breakage during transcription
Aguilera López, Andrés; Gómez González, Belén (Springer Nature, 2017)Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
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Artículo
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
Zatreanu, Diana; Han, Zhong; Mitter, Richard; Tumini, Emanuela; Williams, Hannah C.; Gregersen, Lea Haarup; Dirac-Svejstrup, A. Barbara; Roma, Stefania; Stewart, Aengus; Aguilera López, Andrés; Svejstrup, Jesper (Elsevier, 2019)Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...
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Artículo
Epigenetic features of human telomeres
Cubiles de la Vega, María Dolores; Barroso Ceballos, Sonia Inés; Vaquero Sedas, María Isabel; Enguix González, Alicia; Aguilera López, Andrés; Vega Palas, Miguel Ángel (Oxford University Press, 2018)Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ...
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Artículo
FANCD2 facilitates replication through common fragile sites
Madireddy, Advaitha; Aguilera López, Andrés; Herrera Moyano, Emilia; García Rubio, María Luisa; Owen, Nichole; Olson, Susan (Elsevier, 2016)Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...