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Listar Artículos (Química Orgánica y Farmacéutica) por autor "Lucas Rodríguez, Ricardo"
Mostrando ítems 1-20 de 24
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Apolar carbohydrates as DNA capping agents
Lucas Rodríguez, Ricardo; Vengut Climent, Empar; Gómez Pinto, Irene; Aviñó, Anna; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Royal Society of Chemistry, 2012)Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C–G base pairs. ...
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Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End
Gómez Pinto, Irene; Vengut Climent, Empar; Lucas Rodríguez, Ricardo; Aviñó, Anna; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Wiley-Blackwell, 2013)Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, ...
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Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites
Falomir, Eva; Lucas Rodríguez, Ricardo; Peñalver, Pablo; Martí Centelles, Rosa; Dupont, Alexia; Zafra-Gómez, Alberto; Carda, Miguel; Morales, Juan C. (Wiley-Blackwell, 2016)Resveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability ...
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Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells
López Martín, Sergio; Montserrat de la Paz, Sergio; Lucas Rodríguez, Ricardo; Bermúdez Pulgarín, Beatriz; Abia González, María del Rocío; Morales, Juan C.; García Muriana, Francisco José (Elsevier, 2017)The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative ...
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Glucose-nucleobase pairs within DNA: Impact of hydrophobicity, alternative linking unit and DNA polymerase nucleotide insertion studies
Vengut Climent, Empar; Peñalver, Pablo; Lucas Rodríguez, Ricardo; Gómez Pinto, Irene; Aviñó, Anna; Muro Pastor, Alicia María; Galbis Fuster, Elsa; Paz Báñez, María Violante de; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Royal Society of Chemistry, 2018)Recently, we studied glucose-nucleobase pairs, a binding motif found in aminoglycoside-RNA recognition. DNA duplexes with ...
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Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA
Vengut Climent, Empar; Gómez Pinto, Irene; Lucas Rodríguez, Ricardo; Peñalver, Pablo; Aviñó, Anna; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; Eritja, Ramón; González, Carlos; Morales, Juan C. (Wiley-Blackwell, 2016)Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA ...
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Highly Polar Carbohydrates Stack Onto DNA Duplexes Via CH/π Interactions
Lucas Rodríguez, Ricardo; Gómez Pinto, Irene; Aviñó, Anna; Reina, Jose J.; Eritja, Ramón; González, Carlos; Morales, Juan C. (American Chemical Society, 2011)Carbohydrate-nucleic acid contacts are known to be a fundamental part of some drug-DNA recognition processes. Most of these ...
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Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells
Atzeri, Angela; Lucas Rodríguez, Ricardo; Incani, Alessandra; Peñalver, Pablo; Zafra-Gómez, Alberto; Melis, M. Paola; Pizzala, Roberto; Morales, Juan C.; Deiana, Monica (Royal Society of Chemistry, 2016)The aim of this study was to investigate the ability of the sulfate metabolites of hydroxytyrosol (HT) and tyrosol (TYR) ...
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
Iglesias Blanco, Nieves; Galbis Fuster, Elsa; Romero Azogil, Lucía; Benito Hernández, Elena María; García Martín, María de Gracia; Lucas Rodríguez, Ricardo; Paz Báñez, María Violante de (MDPI, 2020)The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. ...
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Metabolites and tissue distribution of resveratrol in the pig
Azorín-Ortuño, María; Yáñez-Gascón, María J.; Vallejo, Fernando; Pallarés, Francisco J.; Larrosa, Mar; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás-Barberán, Francisco A.; García-Conesa, María T.; Espín, Juan C. (Wiley-Blackwell, 2011-08)Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism ...
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Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release
Iglesias, N.; Galbis Fuster, Elsa; Díaz Blanco, Manuel Jesús; Lucas Rodríguez, Ricardo; Benito Hernández, Elena María; Paz Báñez, María Violante de (MDPI, 2019-01)In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring ...
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Neuroprotective and Anti-inflammatory Effects of Pterostilbene Metabolites in Human Neuroblastoma SH-SY5Y and RAW 264.7 Macrophage Cells
Peñalver, Pablo; Zodio, Sonia; Lucas Rodríguez, Ricardo; Paz Báñez, María Violante de; Morales, Juan Carlos (American Chemical Society, 2020)Oxidative stress is known to be a key factor in many neurodegenerative diseases. Inflammation also plays a relevant role ...
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pH-Responsive Polymeric Nanoparticles as Drug Delivery Systems
Galbis Fuster, Elsa; Paz Báñez, María Violante de; Iglesias, N.; Lucas Rodríguez, Ricardo; Galbis Pérez, Juan Antonio (JSciMed Central, 2017-04)Micelles are excellent devices to be used as controlled drug delivery systems since they exhibit the ability to protect ...
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Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents
Larrosa, Mar; Tomé-Carneiro, Joao; Yáñez-Gascón, María J.; Alcántara, David; Selma, María V.; Beltrán, David; García-Conesa, María T.; Urbán, Cristina; Lucas Rodríguez, Ricardo; Tomás-Barberán, Francisco; Morales, Juan C.; Espín, Juan Carlos (American Chemical Society, 2010-10-28)There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring ...
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Resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives reduce Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes Scott A adhesion to colonic epithelial cell lines
Selma, María V.; Larrosa, Mar; Beltrán, David; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás-Barberán, Francisco; Espín, Juan C. (American Chemical Society, 2012)The efficacy of resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives in inhibiting the adhesion of ...
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Surface-Active Properties of Lipophilic AntioxidantsTyrosol and Hydroxytyrosol Fatty Acid Esters: A PotentialExplanation for the Nonlinear Hypothesis of the AntioxidantActivity in Oil-in-Water Emulsions
Lucas Rodríguez, Ricardo; Comelles, Francisco; Alcántara, David; Maldonado, Olivia S.; Curcuroze, Melanie; Parra, Jose L.; Morales, Juan C. (American Chemical Society, 2001)Our group has recently observed a nonlinear tendency in antioxidant capacity of different hydroxytyrosol fatty acid esters ...
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Synthesis and Antimicrobial Activity of Aminoalkyl Resveratrol Derivatives Inspired by Cationic Peptides
Cebrián, Rubén; Lucas Rodríguez, Ricardo; Fernández Cantos, María Victoria; Slot, Koen; Peñalver, Pablo; Martínez García, Marta; Párraga Leo, Antonio; Paz Báñez, María Violante de; García, Federico; Kuipers, Oscar P.; Morales, Juan Carlos (Taylor & Francis, 2023)Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. ...
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Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations
Aviñó, Anna; Ocampo, Sandra M.; Lucas Rodríguez, Ricardo; Reina, José Juan; Morales, Juan Carlos; Perales, José Carlos; Eritja, Ramón (Springer Nature, 2011)Oligoribonucleotide conjugates and the corresponding siRNA duplexes against tumor necrosis factor carrying one, two, or ...
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Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation
Ugarte Uribe, Begoña; Pérez Rentero, Sonia; Lucas Rodríguez, Ricardo; Aviñó, Anna; Reina, José Juan; Alkorta, Itziar; Eritja, Ramón; Morales, Juan Carlos (American Chemical Society, 2010)Oligonucleotide conjugates carrying carbohydrates at the 5′-end have been prepared. Glucose, fucose, and saccharides ...
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Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates
Vengut Climent, Empar; Terrazas, Montserrat; Lucas Rodríguez, Ricardo; Arévalo Ruiz, Matilde; Eritja, Ramón; Morales, Juan Carlos (Elsevier, 2013)Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been ...