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Mostrando ítems 1-10 de 11
Artículo
Expression of a neu/c-erbB-2-like product in neuroendocrine cells of mammals
(Universidad de Murcia. Departamento de Biología Celular e Histología, 2000-01-01)
The neulc-erbB-2 oncogen encodes a 185 kDa protein closely homologous to the epidermal growth factor receptor. The protein product (p185) is a glycoprotein with an external domain and an internal domain with tyrosine kinase ...
Artículo
Decrease in calcitonin and parathyroid hormone mRNA levels and hormone secretion under long-term hypervitaminosis D3 in rats
(Universidad de Murcia. Departamento de Biología Celular e Histología, 2001-04-25)
In calcium homeostasis, vitamin D3 is a potent serum calcium-raising agent which in vivo regulates both calcitonin (CT) and parathyroid hormone (PTH) gene expression. Serum calcium is the major secretagogue for CT, a hormons ...
Artículo
Clonal patterns in phaeochromocytomas and MEN-2A adrenal medullary hyperplasias: histological and kinetic correlates
(John Wiley & Sons, 2000-06-26)
The relationship among histological features, cell kinetics, and clonality has not been studied in adrenal medullary hyperplasias (AMHs) and phaeochromocytomas (PCCs). Thirty-four PCCs (23 sporadic and 11 MEN-2A (multiple ...
Artículo
cDNA Sequence and Genomic Structure of the Rat Ret Proto-Oncogene
(Informa Healthcare, 2000-06-01)
The RET proto-oncogene, a member of the Receptor Tyrosine Kinase family, plays a crucial role during the development of the excretory system and the enteric nervous system, as demonstrated by in vivo animal studies and by ...
Artículo
Kinetic profiles of intraepithelial and invasive prostatic neoplasias: the key role of down-regulated apoptosis in tumor progression
(Springer, 2000-05)
The cell kinetic of prostatic intraepithelial neoplasia (PIN) is poorly understood. Herein we report the kinetic pattern of PIN, both not associated (primary) and associated (secondary) with coexistent invasive carcinoma ...
Artículo
Artículo
Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?
(Universidad de Murcia. Departamento de Biología Celular e Histología, 2005-07-01)
Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of ...
Artículo
Contribution of the microvessel network to the clonal and kinetic profiles of adrenal cortical proliferative lesions
(W.B. Saunders Co., 2001-11)
Monoclonal adrenocortical lesions have been characterized by an inverse correlation between proliferation and apoptosis, and polyclonal lesions show a direct correlation. Their relationship with the vascular pattern remains ...
Artículo
Clonality as Expression of Distinctive Cell Kinetics Patterns in Nodular Hyperplasias and Adenomas of the Adrenal Cortex
(Elsevier Science, 2000-01)
Although histopathologic criteria for adrenal cortical nodular hyperplasias (ACNHs) and adenomas (ACAs) have been developed, their kinetics and clonality are virtually unknown. We studied 20 ACNHs and 25 ACAs (based on ...
Artículo
Germline RET 634 Mutation Positive MEN 2A-related C-Cell Hyperplasias Have Genetic Features Consistent with Intraepithelial Neoplasia
(The Endocrine Society, 2001-08-01)
C-cell hyperplasias are normally multifocal in multiple endocrine neoplasia type 2A. We compared clonality, microsatellite pattern of tumor suppressor genes, and cellular kinetics of C-cell hyperplasia foci in each thyroid ...