Listar Artículos (Citología e Histología Normal y Patológica) por título
Mostrando ítems 124-143 de 148
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Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization
(Rockefeller University Press, 2021)Rac1 GTPase is hyperactivated in tumors and contributes to malignancy. Rac1 disruption of junctions requires its effector ...
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RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoprotein
(Impact Journals, 2016-06-15)Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate ...
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RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis
(American Association for the Advancement of Science, 2020)Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal ...
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Sarcoma classification by DNA methylation profiling
(Nature Publishing Ggroup, 2021)Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a ...
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Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1
(Nature Publishing Group, 2022)Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying ...
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Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
(Springer Nature, 2021)Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ...
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Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions
(Elsevier, 2021)Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/ activity ...
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Silencing of histone deacetylase 6 decreases cellular malignancy and contributes to primary cilium restoration, epithelial-to-mesenchymal transition reversion, and autophagy inhibition in glioblastoma cell lines
(MDPI, 2021)Glioblastoma multiforme, the most common type of malignant brain tumor as well as the most aggressive one, lacks an effective ...
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Spanish National Registry of Major Osteoporotic Fractures (REFRA) seen at Fracture Liaison Services (FLS): objectives and quality standards
(SPRINGER, 2022)Summary REFRA-FLS is a new registry in Spain aimed at identifying individuals over 50 years of age with a fragility ...
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Surface Modification of Porous Titanium Discs Using Femtosecond Laser Structuring
(MDPI, 2020-06)The failure of titanium implants is associated with two main problems that include the bone resorption and fracture of the ...
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Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials
(Frontiers Media S.A., 2020)Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated ...
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The bitter side of epigenetics: variability and resistance to chemotherapy
(Future Medicine, 2021)One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing ...
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The cadherin–catenin complex in nasopharyngeal carcinoma
(SPRINGER, 2011)Abnormal Wnt signaling and impaired cell–cell adhesion due to abnormal E-cadherin and b-catenin func tion have been ...
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The Fracture Liaison Service of the Virgen Macarena University Hospital Reduces the Gap in the Management of Osteoporosis, Particularly in Men. It Meets the International Osteoporosis Foundation Quality Standards
(MDPI, 2021-09-17)Objectives: To describe the Fracture Liaison Service (FLS), to know the characteristics of the patients attended with ...
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The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity
(IVYSPRING INT PUBL, 2021)Rationale: We recently demonstrated that the ‘Metabesity’ factor HMG20A regulates islet beta-cell functional maturity ...
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The Role of Nitric Oxide in Stem Cell Biology
(MPDI, 2022-03-03)Nitric oxide (NO) is a gaseous biomolecule endogenously synthesized with an essential role in embryonic development and ...
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The second European interdisciplinary Ewing sarcoma research summit – A joint effort to deconstructing the multiple layers of a complex disease
(Impact Journals LLC, 2016-01-18)Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second “European ...
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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
(Nature Research, 2021-09-16)Chromosomal instability (CIN) is a hallmark of cancer1. Yet, many childhood cancers, such as Ewing sarcoma (EwS), feature ...
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Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?
(Universidad de Murcia. Departamento de Biología Celular e Histología, 2005-07-01)Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of ...
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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
(BMC, 2021-07-27)Ewing sarcoma (EwS) is an aggressive bone- or soft tissue-associated malignancy, characterised by the fusion oncoprotein ...