Now showing items 1-3 of 3
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [Article]
(Frontiers Media, 2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin ...
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism [Article]
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was ...
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease [Article]
(rontiers Research Foundation, 2015)
This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the inflammatory response of brain microglia and hence its potential involvement in Parkinson’s ...