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      Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease 

      Salvadores, Natalia; Moreno González, Inés; Gámez, Nazaret; Quiroz, Gabriel; Vegas Gómez, Laura; Escandón, Marcela; Jiménez Muñoz, Sebastián; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Soto, Claudio; Court, Felipe A. (BMC, 2022)
      Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ...
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      Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation 

      Martínez de Pablos, Rocío; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Sarmiento Soto, Manuel; Muñoz Pinto, Mario Faustino; Machado Quintana, Alberto; Venero Recio, José Luis (BioMed Central, 2014)
      Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and ...
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      Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease 

      Muñoz Castro, Clara; Noori, Ayush; Magdamo, Colin G.; Li, Zhaozhi; Marks, Jordan D.; Frosch, Matthew P.; Das, Sudeshna; Hyman, Bradley T.; Serrano Pozo, Alberto (BMC, 2022)
      Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s ...
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      Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology 

      Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
      Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
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      Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon 

      Espinosa Oliva, Ana María; García Miranda, Pablo; Alonso Bellido, Isabel María; Carvajal Vázquez, Ana Eloisa; González Rodríguez, Melania; Carrillo Jiménez, Alejandro; García Domínguez, Irene; Vázquez Carretero, María Dolores; García Revilla, Juan; Santiago Pavón, Martiniano; Peral Rubio, María José; Venero Recio, José Luis; Martínez de Pablos, Rocío (Frontiers Media, 2021)
      Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ...
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      Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease 

      Boza Serrano, Antonio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; García Revilla, Juan; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2019)
      Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
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      Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease 

      García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020)
      Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
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      Inflammatory Animal Models of Parkinson's Disease 

      García Revilla, Juan; Herrera Carmona, Antonio José; Martínez de Pablos, Rocío; Venero Recio, José Luis (IOS Press, 2022)
      Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis ...
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      LPS priming before plaque deposition impedes microglial activation and restrains Abeta pathology in the 5xFAD mouse model of Alzheimer's disease. 

      Yang, Yiyi; García Cruzado, Marta; Zeng, Hairuo; Camprubi Ferrer, Lluis; Bahatyrevich Kharitonik, Bazhena; Bachiller, Sara; Deierborg, Tomas (Elsevier, 2023-10)
      Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative ...
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      Microglia: Agents of the CNS Pro-Inflammatory Response 

      Rodríguez Gómez, José Antonio; Kavanagh, Edel T.; Engskog-Vlachos, Pinelopi; Engskog, Mikael; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Joseph, Bertrand; Hajji, Nabil; Venero Recio, José Luis; Burguillos García, Miguel Ángel (Multidisciplinary Digital Publishing Institute (MDPI), 2020)
      The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative ...
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      Microglial Caspase-3 is essential for modulating hippocampal neurogenesis. 

      Alonso Bellido, Isabel María; Posada Pérez, Mercedes; Hernández Rasco, Francisco; Vázquez Reyes, Sandra; Cabanillas, María; Herrera Carmona, Antonio José; Soldán Hidalgo, Jesús; Espinosa Oliva, Ana María; Martínez de Pablos, Rocío; Venero Recio, José Luis; Ruiz Laza, Rocío (Elsevier, 2023)
      Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have ...
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      Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus 

      Muñoz-Castro, Clara; Mejías Ortega, Marina; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Trujillo Estrada, Laura; Jiménez, Sebastián; García León, Juan Antonio; Fernández Valenzuela, Juan José; Sánchez Mico, María Virtudes; Romero Molina, Carmen; Moreno González, Inés; Baglietto Vargas, David; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer Nature, 2023)
      Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...
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      Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease 

      Romero Molina, Carmen; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Mico, María; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
      Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...
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      Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke 

      Rodhe, Johanna; Burguillos García, Miguel Ángel; Martínez de Pablos, Rocío; Kavanagh, Edel T.; Persson, Annette; Englund, Elisabet; Venero Recio, José Luis (BioMed Central, 2016)
      Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells ...
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      The human bone marrow harbors a CD45− CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches 

      Bruzelius, Andreas; Hidalgo, Isabel; Boza Serrano, Antonio; Hjelmér, Anna Giorgia; Tison, Amelie; Deierborg, Tomas; Bengzon, Johan; Ramos Moreno, Tania (Wiley-Blackwell, 2021)
      Microglia, the immune sentinel of the central nervous system (CNS), are generated from yolk sac erythromyeloid progenitors ...
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      The role of Galectin-3 in α-synuclein-induced microglial activation 

      Boza Serrano, Antonio; Reyes, Juan F.; Rey, Nolwen L.; Leffler, Hakon; Bousset, Luc; Nilsson, Ulf J.; Brundin, Patrik; Venero Recio, José Luis; Burguillos García, Miguel Ángel; Deierborg, Tomas (BioMed Central, 2014)
      Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology ...
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      Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis 

      Sánchez Varo, Raquel María; Mejías Ortega, Marina; Fernández Valenzuela, Juan José; Núñez Díaz, Cristina; Cáceres Palomo, Laura; Vegas Gómez, Laura; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; García León, Juan Antonio; Moreno González, Inés; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Baglietto Vargas, David; Gutiérrez Pérez, Antonia (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
      Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease ...