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Patente. Invención
Combinaciones de proteínas agregantes y chaperonas moleculares para el tratamiento de proteinopatías o enfermedades conformacionales
(Organización Mundial de la Propiedad Intelectual (OMPI), 2015-03-19)
Las HSPs (chaperonas o proteínas de choque térmico ('heat-shock proteins' o HSPs)) poseen dos características muy valiosas que podrían ser explotadas productivamente y de forma específica para una manipulación 'inteligente' ...
Artículo
Tesis Doctoral
Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones
(2017-05-22)
This Doctoral Thesis is focused on the interplay between the immune system and the Parkinson’s related protein alpha-Synuclein. The first part of this work was to study the impact of extracellular aSyn priming on the ...
Artículo
Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation
(PLOS, 2013)
In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, which accompanies the development of Parkinson's disease and other related disorders, such as ...