Now showing items 1-3 of 3

    • Icon

      A Dynamic Kinetic Asymmetric Heck Reaction for the Simultaneous Generation of Central and Axial Chirality  [Article]

      Carmona, José A.; Hornillos, Valentín; Ramírez López, Pedro; Ros Lao, Abel; Iglesias Sigüenza, Francisco Javier; Gómez-Bengoa, Enrique; Fernández Fernández, Rosario Fátima; Lassaletta, José M. (American Chemical Society, 2018)
      A highly diastereo- and enantioselective, scalable Pd-catalyzed dynamic kinetic asymmetric Heck reaction of heterobiaryl sulfonates with electron-rich olefins is described. The coupling of 2,3-dihydrofuran or N-boc protected ...
    • Icon

      A Practical Synthesis of Enantiopure 4,5-Dihydroisoxazole-5-carboxylic Acids  [Article]

      Ros Lao, Abel; Álvarez González, Eleuterio; Dietrich, Hansjörg; Batarda Fernandes, Rosario; Lassaletta Simón, José María (2005)
      The 1,3-dipolar cycloaddition of a variety of aromatic and aliphatic nitrile oxides to 2,5-trans-2,5-diphenylpyrrolidine derived acrylamide and cinnamamide efficiently affords the corresponding 4,5-dihydroisoxazole-5- ...
    • Icon

      Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation  [Article]

      Hornillos, Valentín; Carmona, José A.; Ros Lao, Abel; Iglesias Sigüenza, Francisco Javier; López Serrano, Joaquín; Fernández Fernández, Rosario Fátima; Lassaletta, José M. (Wiley, 2018)
      Adiastereo- and highly enantioselective dynamic kinetic resolution (DKR) of configurationally labile hetero- biaryl ketones is described. The DKR proceeds by zinc- catalyze dhydrosilylation of the ...