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Listar Artículos (Química Orgánica) por autor "Robina Ramírez, Inmaculada"
Mostrando ítems 1-20 de 26
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Artículo
Amine-linked diglycosides: synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays
Moreno Clavijo, Elena; Cumpstey, Ian; Frigell, Jens; Pershagen, Elias; Akhtar, Tashfeen; Alonzi, Dominic S.; Butters, Terry D.; Robina Ramírez, Inmaculada (2011) -
Artículo
Azabicyclic vinyl sulfones for residue-specific dual protein labelling
Gil de Montes Rojas, Enrique; Jiménez Moreno, Ester; Oliveira, Bruno L.; Navo, Claudio D.; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Royal Society of Chemistry, 2019)We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification ...
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Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
Elías Rodríguez, María del Pilar; Pingitore, Valeria; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Ide, Daisuke; Miyawaki, Shota; Kato, Atsushi; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada (American Chemical Society, 2018)The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ...
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Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022)Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
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Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes
Carranza César, Marina; Carmona Asenjo, Ana Teresa; Navo, Claudio D.; Robina Ramírez, Inmaculada; Fratta, Simone; Newburn, Carlos; Jimenez-Oses, Gonzalo; Moreno Vargas, Antonio José (American Chemical Society, 2023)2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ...
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Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
Matassini, Camilla; Mirabella, Stefania; Goti, Andrea; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Cardona, Francesca (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported ...
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Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020)Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
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Artículo
Gold nanoparticles are suitable cores for building tunable iminosugar multivalency
Matassini, Camilla; Marradi, M.; Cardona, F.; Parmeggiani, C.; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Penadés, S.; Goti, A. (Royal Society of Chemistry: Open Access, 2015)The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward ...
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Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines
Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...
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Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket
Monaco, Serena; Ramírez Cárdenas, Jonathan; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Multidisciplinary Digital Publishing Institute (MDPI), 2022)In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ...
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Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
Mirabella, Stefania; D'Adamio, Giampiero; Matassini, Camilla; Goti, Andrea; Delgado, Sandra; Gimeno, Ana; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Šesták, Sergej; Jiménez Barbero, Jesús; Cardona, Francesca (Wiley-Blackwell, 2017)Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ...
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Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds
Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Moreno Clavijo, Elena; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft, 2011)We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest.
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Preparation of water-soluble glycopolymers derived from five-membered iminosugars
Martínez Bailen, Macarena; Galbis Fuster, Elsa; Carmona Asenjo, Ana Teresa; Paz Báñez, María Violante de; Robina Ramírez, Inmaculada (Elsevier, 2019-10)Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. ...
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Artículo
Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation
Gil de Montes, Enrique; Istrate, Alena; Navo, Claudio D.; Jiménez Moreno, Ester; Hoyt, Emily A.; Corzana, Francisco; Robina Ramírez, Inmaculada; Jiménez Osés, Gonzalo; Moreno Vargas, Antonio José; Bernardes, Gonçalo J.L. (Wiley-Blackwell, 2020)An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction ...
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Artículo
Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars
Molina, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada (Georg Thieme Verlag, 2006)The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology ...
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Artículo
Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019)The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...
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Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
Franco, Jorge; Piacente, Francesco; Walter, Melanie; Fratta, Simone; Ghanem, Moustafa; Benzi, Andrea; Martínez Bailén, Macarena; Robina Ramírez, Inmaculada; Del Río, Alberto (Multidisciplinary Digital Publishing Institute (MDPI), 2022)NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ...
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Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors
Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Molina Sanz, Lidia; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
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Artículo
Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
Coste, G.; Horlacher, T.; Molina Sanz, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Seeberger, P.H.; Gerber-Lemaire, S. (Thieme Publishing; Georg Thieme Verlag, 2011)Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ...
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Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives
Elías Rodríguez, María del Pilar; Moreno Clavijo, Elena; Carrión Jiménez, Sebastián; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Caffa, I.; Montecucco, F.; Cea, M.; Nencioni, A.; Robina Ramírez, Inmaculada (Arkat USA, 2014)A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ...