Now showing items 1-4 of 4

    • IconCyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities  [Article]

      Aguilar Moncayo, Eva M.; Guilloteau, Nicolas; Bienvenu, Céline; Jiménez Blanco, José Luis; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2014)
      Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining cationic centers and carbohydrate motifs into monodisperse architectures has been proposed as a ...
    • Icon(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties  [Article]

      Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Ortiz Mellet, Carmen; García Fernández, José Manuel (Beilstein-Institut, 2010)
      Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. However, a distinct disadvantage of naturally occurring oligosaccharides is their metabolic instability ...
    • IconSynthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors  [Article]

      Jiménez Blanco, José Luis; Rubio, Enrique M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (2004)
      Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a variety of nitriles results in the formation of fused or spiro 2-oxazolines. The reaction implies (i) ...
    • IconTrehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties  [Article]

      Carbajo-Gordillo, Ana I.; Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José Manuel (The Society, 2019-06-19)
      An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate ...